Monday, November 28, 2011

Animal Hats from ShopOnlineDeals.com (FREE SHIPPING)

Look! Out there in the wild! Walking the streets! Is that a red fox being chased by paparazzi or is it Kloe Kardashian? Do we spy a rare Chinese panda bear coming out of Starbucks or could it just be Vanessa Hudgens? Do our eyes deceive us? Is that rather comely-looking cheetah none other than Rihanna?

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May purchase multiple vouchers. May purchase multiple as gifts. Valid for online orders only. May only redeem 1 voucher at a time. Cannot be combined with any other offers or specials. Tax not included. Cash value, credit, or change will not be given. Shipping is included! *In addition to your order confirmation, you will receive an email within 48 hours with your promo code to enter when placing your order at www.shoponlinedeals.com.
A gift certificate will be mailed to you in 2?3 business days. Home printing is not currently available for this item.

There are no reviews for this product at this time.

Source: http://halfoffdepot.com/phoenix/catalog/product/view/id/8420/

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Video: Trend Tracker: Gingrich, Pakistan, Romney in Iowa

October 30: Plouffe, roundtable

Nearly a year away from the 2012 election, we?ll talk to the president?s 2008 campaign manager, now White House Senior Adviser, David Plouffe. Then author of the definitive new biography on the late Apple CEO, Steve Jobs, Walter Isaacson; Author of the new book ?The Time of Our Lives,? NBC News Special Correspondent, Tom Brokaw; Former Governor of Michigan, Jennifer Granholm; and Republican strategist, Mike Murphy.

Source: http://www.msnbc.msn.com/id/3032608/vp/45452930#45452930

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Akamai Reportedly Buying Rival Cotendo For Up To $350 Million

cotendoClassify this as a rumor for now, but Israeli business press is reporting that Akamai is poised to take over one of its competitors, website and mobile acceleration technology vendor Cotendo, for $300 million to $350 million. Founded in 2008, Cotendo has raised over $36 million in funding from investors like Sequoia Capital, Benchmark Capital and Tenaya Capital. A few months ago, Cotendo raised $17 million in new funding from its previous backers, with Citrix Systems and Juniper Networks stepping in as strategic investors as well.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/RzneMXv8wec/

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Sunday, November 27, 2011

Stocks tank as Italy debt fears resurface

People check share prices on an electronic indicator in Tokyo, Friday, Nov. 25, 2011 as the 225-issue Nikkei Stock Average, shown top row center, lost 5.17 points to close at 8,160.01. Asian stock markets were mostly lower Friday after Germany continued to oppose a bigger role for the European Central Bank in managing the continent's debt crisis and Portugal's credit rating was lowered to junk. (AP Photo/Shizuo Kambayashi)

People check share prices on an electronic indicator in Tokyo, Friday, Nov. 25, 2011 as the 225-issue Nikkei Stock Average, shown top row center, lost 5.17 points to close at 8,160.01. Asian stock markets were mostly lower Friday after Germany continued to oppose a bigger role for the European Central Bank in managing the continent's debt crisis and Portugal's credit rating was lowered to junk. (AP Photo/Shizuo Kambayashi)

A man walks past an electronic stock indicator in Tokyo, Friday, Nov. 25, 2011, as the 225-issue Nikkei Stock Average, shown top row center, lost 5.17 points to close at 8,160.01. Asian stock markets were mostly lower Friday after Germany continued to oppose a bigger role for the European Central Bank in managing the continent's debt crisis and Portugal's credit rating was lowered to junk. (AP Photo/Shizuo Kambayashi)

LONDON (AP) ? Stocks took another pounding Friday after Italy's borrowing rates ratcheted higher following a pair of hugely disappointing auctions from the eurozone's third-largest economy.

The auction results are another sign that Italy's new technocratic government faces a big battle to convince the markets it has a strategy to get a grip on the country's massive debts. It also served as a reminder that Europe's debt crisis has clearly spread from its relatively small economies to big countries such as Italy and Spain.

Italy had to pay an average yield of 7.814 percent to raise euro2 billion ($2.67 billion) in two-year bills. That rate was sharply higher on the 4.628 percent it had to pay in the previous auction in October. And even raising euro8 billion ($10.7 billion) for six months proved exorbitantly expensive. The yield for this auction spiked to 6.504 percent, nearly double the 3.535 percent rate in the last equivalent auction last month.

Following the grim news on the auction front, Italy's borrowing rates in the markets skyrocketed, with the ten-year yield spiking 0.34 percentage point to 7.30 percent ? above the 7 percent threshold that is widely considered unsustainable in the long-run and eventually forced Greece, Ireland and Portugal had to seek financial bailouts.

The renewed rise is likely to renew tensions over Italy's debts, which stand at euro1.9 trillion ($2.6 trillion), or a huge 120 percent of its economic output. Europe's current anti-crisis measures are too not big enough to deal with Italy's debt mountain

Against this backdrop, markets in Europe continued their long losing streak. Germany's DAX was down 0.6 percent at 5,396 while the CAC-40 in France fell 0.7 percent to 2,802. Britain's FTSE 100 index of leading British shares was 0.5 percent lower at 5,101 but Italy's main FTSE MIB index underperformed them all, trading 1.8 percent lower.

The euro also took a hit, trading 0.7 percent lower at $1.3234, a fresh seven-week low.

Wall Street was poised for a lower opening too though trading is expected to be fairly light as many traders will remain away for a long Thanksgiving holiday weekend. Dow futures were 0.7 percent lower at 11,160 while the broader Standard & Poor's 500 futures fell 0.8 percent to 1,151.

Aside from Europe's debt crisis, traders in the U.S. were bracing for a crucial test of the world's No. 1 economy ? so-called Black Friday, the day that kicks off the holiday shopping season. How well retailers do will have consequences for the still-fragile U.S. economic recovery, as well as for the global economy.

Adding to the negative sentiment was Moody's downgrading of Hungary's credit rating to junk status late Thursday.

Hungary, which last week asked the International Monetary Fund and the European Union for possible financial help, is feeling the fallout from the debt crisis in the 17-country eurozone, even though it does not use the euro. Its economy has not grown as much as hoped and its debt burden remains relatively high.

"While not really a market-moving event, the downgrading of Hungarian bonds to junk status still served to highlight that the same old European debt problems remain - and many traders feel there is still the same old lack of urgency from politicians," said David Jones, chief market strategist at IG Index.

Earlier in Asia, trading was sluggish. Japan's Nikkei 225 index closed marginally down at 8,160.01 while Hong Kong's Hang Seng dropped 1.4 percent to 17,689.48.

In mainland China, the benchmark Shanghai Composite Index lost 0.7 percent to 2,380.22, its lowest closing level in a month.

Benchmark crude for January delivery was down 2 cents at $96.11 a barrel in electronic trading on the New York Mercantile Exchange. The contract last settled on Wednesday in New York at $96.17, down $1.84.

___

Pamela Sampson in Bangkok contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-11-25-World-Markets/id-328e48396c044087a4adfac930b19915

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Saturday, November 26, 2011

RIM's giving away PlayBooks to enterprise customers, might start begging soon

It slashed prices, promised the moon on a stick for next year's OS upgrade and now Research in Motion has resorted to just giving the beleaguered BlackBerry PlayBook away. Purchase a copy of BlackBerry Enterprise Server v5 between now and the end of the year and you'll bag a free 16GB tablet. The offer is open to everyone in the United States and Canada -- except Quebec -- who want the only tablet that's packing the full BlackBerry experience (sans email, messaging, calendar...).

RIM's giving away PlayBooks to enterprise customers, might start begging soon originally appeared on Engadget on Sat, 26 Nov 2011 02:11:00 EDT. Please see our terms for use of feeds.

Permalink Electronista  |  sourceRIM  | Email this | Comments


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/KPhmpyAkrfM/

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Health Tip: Don't Take Too Many NSAIDs (HealthDay)

(HealthDay News) -- Nonsteroidal anti-inflammatory drugs (NSAIDs) have been around for years and are frequently the medication of choice to relieve pain and inflammation.

But taking too many of this type of drug, which includes aspirin, ibuprofen and naproxen, can lead to potential complications, including stomach bleeding or ulcer.

The American Gastroenterological Association says reasons for potential NSAID overdose include:

  • Taking a subsequent dose too soon after taking the initial one.
  • Taking more of the medication at one time than is recommended.
  • Taking a higher dose over a 24-hour period than is recommended.
  • Taking more than one NSAID-containing medication at a time

Source: http://us.rd.yahoo.com/dailynews/rss/meds/*http%3A//news.yahoo.com/s/hsn/20111124/hl_hsn/healthtipdonttaketoomanynsaids

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Moroccans hold Arab Spring-inspired election

A Moroccan woman leaves a polling booth before casting her vote in a polling station in Rabat, Morocco, Friday, Nov. 25, 2011. Moroccans began voting for a new parliament Friday in Arab Spring-inspired elections that are facing a boycott by democracy campaigners who say the ruling monarchy isn't committed to real change. Small sign reads: voting booth. (AP Photo/Abdeljalil Bounhar)

A Moroccan woman leaves a polling booth before casting her vote in a polling station in Rabat, Morocco, Friday, Nov. 25, 2011. Moroccans began voting for a new parliament Friday in Arab Spring-inspired elections that are facing a boycott by democracy campaigners who say the ruling monarchy isn't committed to real change. Small sign reads: voting booth. (AP Photo/Abdeljalil Bounhar)

Abdelilah Benkirane, the secretary general of Morocco's Islamist Justice and Development Party, leaves the voting booth in Rabat, Morocco, Friday, Nov. 25, 2011. Moroccans began voting for a new parliament Friday in Arab Spring-inspired elections that are facing a boycott by democracy campaigners who say the ruling monarchy isn't committed to real change. (AP Photo/Abdeljalil Bounhar)

Moroccan Finance Minister Salaheddine Mezouar, tipped as possibly the next prime minister, casts his ballot in the affluent neighborhood of Souissi, Rabat. Moroccans voted on Friday Nov. 25, 2011 in parliamentary elections brought forward as part of the king's package of reforms to respond to the Arab Spring. (AP Photo/Paul Schemm)

A man clutching his car keys and smartphone votes in the affluent Rabat neighborhood of Agdal early in the morning Friday Nov. 25 2011. Moroccans voted Friday in parliamentary elections brought forward as part of the king's package of reforms to respond to the Arab Spring. (AP Photo/Paul Schemm)

A woman deposits her ballot paper after voting in Rabat, Morocco, Friday, Nov. 25, 2011. Moroccans voted for a new parliament Friday in Arab Spring-inspired elections that are facing a boycott by democracy campaigners who say the ruling monarchy isn't committed to real change. (AP Photo/Abdeljalil Bounhar)

(AP) ? Moroccans voted for a new parliament Friday in Arab Spring-inspired elections that are facing a boycott by democracy campaigners who say the ruling monarchy isn't committed to real change.

A moderate Islamist party and a pro-palace coalition led by the finance minister are competing for the top spot, but a key test for the authorities' legitimacy will be how many voters cast ballots.

The king amended the constitution over the summer giving the prime minister new powers, including the ability to dissolve parliament and make certain appointments, in response to pro-democracy protests. But the ultimate authority remains with the king.

The election result will be closely watched by Morocco's U.S. and other Western allies, as well as European tourists who cherish its beaches and resorts, to see how this North African kingdom navigates its own Arab Spring.

In the affluent Agdal neighborhood of Rabat, a steady stream of professionals lined up early in the morning at a polling station to vote before work.

"I've always voted, but this time it is more important," said Dr. Mohammed Ennabli. "Before it was the king who chose, now it is the people who choose."

Many people, however, scorned a process they say has been going on for decades without any tangible effect on their lives.

"I won't vote, the promises are never kept ? with or without the new constitution, it is the same," said Abdallah Cherachaoui, an unemployed 45 year old in the lower income district of Akkari. "They are laughing at us."

In the working class city of Sale, across the river from the capital Rabat, there was a steady trickle of voters to the school acting as a polling station, but some stayed outside.

"I voted in 2007 because the candidate was a member of my family, but he also disappointed me and as soon as the elections were over, I never saw him again, so I'm not making that mistake again," said Brahim Errami, 25, from his seat in a nearby cafe. "I pity the people going in and out of that school."

Morocco's reputation as a stable kingdom in North Africa has taken a hit with this year's protests over government corruption and heavy handed security forces. And its once-steady economy is creaking from the amount of money the government has pumped into raising salaries and subsidies to keep people calm amid the Arab world turmoil.

The election campaign has been strangely subdued, unlike the lively politicking in nearby Tunisia when it held the first elections prompted by the Arab uprisings last month.

Morocco with its many political parties and regular elections under the tight control of an all-powerful monarch was once the bright star in a region of dictatorships.

But all that has changed with the Arab uprisings that toppled dictators in Tunisia, Libya and Egypt. Now a political system that holds elections but leaves all powers in the hands of a hereditary king does not look so liberal.

Some 31 political parties are fielding 5,392 candidates to compete for 395 seats in parliament, including 60 set aside for women and 30 for "youth," under 40.

A complex proportional system of representation means no party is likely to take more than 20 percent of the seats.

Under the new constitution, the king asks the party with the most seats to form the government, which could well be the Islamist Justice and Development party, known by its French initials PJD. But there's uncertainty over whether it can truly change anything in the face of the palace's power.

The Islamists' biggest rival for the top spot is Finance Minister Salaheddine Mezouar's Rally of Independents, which leads an alliance of seven other pro-palace parties.

"This is a very important election for the Moroccan people and it confirms the choice made for an open process of democratization that is being consolidated by this election," he told The Associated Press after voting. "This is really a moment of great emotion."

Like elsewhere in the Arab world, Moroccans hit the streets in the first half of 2011 calling for more democracy, and King Mohammed VI responded by amending the constitution and bringing forward elections.

But since then the sense of change has dissipated, and while the king remains a respected figure, few have much confidence in parliament or the politicians in it.

"I voted because we need to elect a new parliament, but I voted blank for the simple reason that there is no one I can trust from the people that are being elected," said Chamseddin Baba, the manager of an IT company who voted in the wealthy suburb of Souissi. "I would like to vote for the best, but the best are not there."

The 2007 elections, the first with widespread international observation, had just 37 percent turnout, and some fear it could be even lower this time around.

Now, however, the number of registered voters has dropped from 15 million to 13.5 million, despite population increases, so turnout will almost certainly be higher.

There will be 3,200 election observers, though they will likely only cover a fraction of the 40,000 polling stations scattered across the country.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-11-25-ML-Morocco-Elections/id-a41decf2f084425883da0ded59a48c3e

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Thursday, November 24, 2011

The Huntsman Dilemma (Prospect)

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European Galaxy Nexus owners complain of erratic volume issue (video)

Samsung's new flagship smartphone isn't having the smoothest of beginnings. The strange ROM that cropped up a few days ago turned out to be an isolated incident, but now the forums are abuzz with an audio issue that looks a lot more serious. Essentially, the handset's volume control appears to have a mind of its own, flitting randomly between mute, full blast and everything in between. The problem has so far only been observed on European phones using the GSM 900MHz band, and it's exacerbated by the cellular modem either boosting itself in a low reception area or switching between 2G and 3G connections. A user poll over at the XDA Developers forum suggests around 60 percent of owners have experienced the fault. There's a video after the break, complete with a disappointed kid in the background bugging his dad for answers.

Continue reading European Galaxy Nexus owners complain of erratic volume issue (video)

European Galaxy Nexus owners complain of erratic volume issue (video) originally appeared on Engadget on Mon, 21 Nov 2011 07:40:00 EDT. Please see our terms for use of feeds.

Permalink Gizmodo  |  sourceDuddyroar (YouTube), XDA Developers (forum)  | Email this | Comments

Source: http://www.engadget.com/2011/11/21/european-galaxy-nexus-owners-complain-of-erratic-volume-issue-v/

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Wednesday, November 23, 2011

HBT: Marlins think Pujols older than he says he is

An interesting read from Dan Le Batard in the Miami Herald about how the Marlins are going about ? or at least appear to be going about ? transforming the franchise. Going big and trying to establish a Latin brand.

Part of that, of course, is the pursuit, such as it is, of Albert Pujols. ?A pursuit that is as lukewarm as it is because of a small concern on the part of some in Miami?s front office:

The total dollars are in dispute, depending on whom you believe, but the number of years offered is not. Nine years. That?s insanity, especially since, like a lot of teams,?the Marlins believe Pujols to be older than the 31 he claims to be.

This gets whispered about a lot. And I?ve never seen any more meat put on those bones than you see in one of those ?that dude must be on steroids; look at this physique!? arguments.

Over at Baseball Musings, however, David Pinto makes a pretty simple and compelling case that Pujols? career progression is totally in keeping with someone who is his stated age.

Call me back if there?s ever anything more to this. Until then, I don?t think it?s fair to make any assumptions about Pujols? age.

Source: http://hardballtalk.nbcsports.com/2011/11/20/the-marlins-think-albert-pujols-is-older-than-he-says-he-is/related/

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Police clear Oakland protest camp without incident (Reuters)

OAKLAND, California (Reuters) ? Police on Sunday cleared anti-Wall Street protesters from a vacant lot and public park in Oakland, California, a day after they had erected a tent camp to replace one torn down by authorities.

There were no reports of arrests or violence.

Previous unrest surrounding protests in Oakland, a West Coast Occupy hot spot, helped rally support nationwide for the Occupy Wall Street movement launched in New York in September to protest economic inequality and excesses of the U.S. financial system.

Oakland Mayor Jean Quan said the cost of the encampments to the city was growing and putting a strain on already fragile resources including police, public works and other staff.

Quan said in a statement that Sunday's raid was necessary and that public safety and protecting downtown businesses from vandalism are the city's priority.

"We will not tolerate lodging on public property, whether in parks or open space; it is illegal," Quan said.

Oakland police spokeswoman Johanna Watson said the protesters were "very cooperative" and police encountered no resistance.

A previous effort to remove the protesters' camp in October sparked clashes between protesters and police that wounded a former U.S. Marine and turned into one of the most violent episodes linked to the Occupy movement.

The protesters had pitched tents in the lot and adjacent park on Saturday. Police less than a week ago dismantled a similar protest camp nearby.

Oakland protesters have announced plans to shut down all West Coast ports on December 12 in coordination with like-minded protesters in Los Angeles.

To the north, two University of California, Davis police officers have been placed on administrative leave while the school investigates the apparent use by campus police of pepper spray against seated student protesters, the university said on Sunday.

(Editing by Ellen Wulfhorst and David Bailey)

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/nm/20111121/us_nm/us_protests_westcoast

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Tuesday, November 22, 2011

UFC 139 postfight: ?Shogun? says fifth could?ve been a 10-8 and wants a rematch against Henderson

UFC 139 postfight: ?Shogun? says fifth could?ve been a 10-8 and wants a rematch against HendersonSAN JOSE, Calif. - Many along press row at the HP Pavilion were a little surprised not one judge gave Mauricio "Shogun" Rua a 10-8 for his efforts in the fifth round of his fight against Dan Henderson. It turns out Rua was surprised as well.

"I don't know how the judges scored the last round. It could have been or should have been a 10-8 round. But that doesn't take anything away from Dan Henderson. He is a legend and those are the type of fights that create a legacy," said Rua.

Rua is looking forward to seeing a replay of the fight.

"I'm going to rest with my family now and take care of myself. Then I'm going to go back and look at the tapes. I want a rematch and I think this would be another great battle and one the fans would definitely want to see," said Rua.

FightMetric backed up Rua. The Brazilian outlanded Henderson 26-0 in significant strikes over the final minutes and 79-8 overall in the fifth.

John Morgan, 2009 MMA Journalist of the Year, scored it a draw as did Adam Hill from the Las Vegas Review-Journal. ESPN.com's Brett Okamoto scored it 48-46 for Rua.

Will Angland at Bleacher Report wrote a strong piece saying Rua was robbed.

Source: http://sports.yahoo.com/mma/blog/cagewriter/post/UFC-139-postfight-8216-Shogun-8217-says-fif?urn=mma-wp9815

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Kampmann survives early rush, to finish strong and edge Story at UFC 139

SAN JOSE, Calif. - Martin Kampmann's been around for a long time so he wasn't going to fold when Rick Story pressed him early. The veteran let Story gas himself and took over in the second half of the fight to pick up a split decision victory, 30-27, 29-28 and 28-29 in fight No. 2 of the UFC 139 pay-per-view at the HP Pavilion.

Story looked dynamite early in the fight. His volume was blowing away Kampmann, who appear to be a little tight in the first three minutes of the fight. Kampmann, who suffered a small cut on his forehead during the early onslaught, has a chin because he absorbed some heavy shots. It may have discouraged Story to see Kampmann standing in front shaking his head that the shots weren't hurting.

Kampmann (18-5, 9-4 UFC) further broke down Story's will with a very effective jab. By the end of the first round, which looked like it was going to be a cakewalk, Story had his own cut over his right eye.

Story's a good wrestler, but he was taken down in each of the final two rounds.

Source: http://sports.yahoo.com/mma/blog/cagewriter/post/Kampmann-survives-early-rush-to-finish-strong-a?urn=mma-wp9727

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A glance at new sanctions imposed on Iran (AP)

The Obama administration announced a new set of sanctions against Iran on Monday in an effort to apply greater pressure to get Tehran to halt its suspected nuclear weapons program.

The new sanctions, which were coordinated with Britain and Canada, build on elements of previous sanction efforts. The efforts announced Monday:

_Use a section of the Patriot Act to identify for the first time Iran's entire banking sector, including the country's central bank, as a threat to other governments and institutions. The designation of Iran as a "primary money laundering concern" will require increased monitoring by U.S. banks to make sure that they and their foreign affiliates are avoiding all contact with Iranian financial institutions. The United States was joined in this action by Britain and Canada.

_Impose sanctions on Iran's petrochemical industry, prohibiting U.S. companies from providing goods, services and technology to support Iran's production of petrochemicals. This industry represents Iran's second biggest export after crude oil.

_Expands existing energy sanctions with the aim of making it more difficult for Iran to operate, maintain and modernize its oil and gas sector.

_Designates 11 individuals and business entities for sanctions because of their alleged roles in assisting Iran's prohibited nuclear programs.

Source: http://us.rd.yahoo.com/dailynews/rss/iran/*http%3A//news.yahoo.com/s/ap/20111122/ap_on_go_ca_st_pe/us_us_iran_sanctions_glance

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Monday, November 21, 2011

Super committee stalemate continues as deadline nears (Los Angeles Times)

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[OOC] Pairings

Forum rules
This forum is for OOC discussion about existing roleplays.

Please post all "Players Wanted" threads in the Roleplayers Wanted forum!

This topic is an Out Of Character part of the roleplay, ?Love and it's consequences?. Anything posted here will also show up there.

Topic Tags:

Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.

So for the pairings, each guy is going to pick the top two girls he'd like his chachter with. One of them will be his mate, the other will be his true love. So even if some is picked twice, they dont have to fight over her. (fun as that may be.) One person will have them as their mate, the other will have her as their true love. I pick the mate/true love part.

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Horseygirl
Member for 2 years



Return to Out of Character

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Weak spot discovered on deadly ebolavirus

ScienceDaily (Nov. 20, 2011) ? Scientists from The Scripps Research Institute and the US Army's Medical Research Institute of Infectious Diseases have isolated and analyzed an antibody that neutralizes Sudan virus, a major species of ebolavirus and one of the most dangerous human pathogens.

"We suspect that we've found a key spot for neutralizing ebolaviruses," said Scripps Research Associate Professor Erica Ollmann Saphire, who led the study with US Army virologist John M. Dye.

The new findings, which were reported November 20, 2011, in an advance online edition of Nature Structural & Molecular Biology, show the antibody attaches to Sudan virus in a way that links two segments of its coat protein, reducing their freedom of movement and severely hindering the virus's ability to infect cells. The protein-linking strategy appears to be the same as that used by a previously discovered neutralizing antibody against the best-known ebolavirus species, Ebola-Zaire. The new study suggests that this may be the best way for vaccines and antibody-based therapies to stop ebolaviruses.

Deadly Outbreaks

Ebolaviruses first drew the attention of the medical world with simultaneous deadly outbreaks in 1976 in the nations of Sudan and Zaire (currently known as the Democratic Republic of the Congo). These two outbreaks were caused by the two major viruses: Ebola-Sudan and Ebola-Zaire, and early field studies showed that sera from patients that survived one virus could not help patients infected with the other. . Both viruses persist in animal hosts-probably bats-and when they spread to humans, typically cause severe hemorrhagic fevers, killing up to 90 percent of people they sicken. Although not as contagious as influenza or measles, ebolaviruses can be transmitted in bodily fluids including exhaled airborne droplets, and scientists who study these viruses are generally required to use special "Biosafety Level 4" facilities. The US government regards the ebolaviruses as a potential bioterror threat.

Ebolavirus researchers hope to develop a vaccine that could be used to protect health workers and others in the vicinity of ebolavirus outbreaks, as well as an antibody-based immunotherapy that could help infected people survive. However, these tasks are complicated by the fact that there are now five recognized species of ebolavirus: Ebola-Zaire, also known simply as Ebola virus; Ta? Forest virus; Reston virus; Bundibugyo virus; and Sudan virus.

"These species differ enough from each other that neutralizing antibodies to one don't protect against the rest," said Ollmann Saphire. "Sudan virus is a particular concern because it has caused about half of the ebolavirus outbreaks so far, including the largest outbreak yet recorded."

Uncovering the Body's Natural Protection

US government researchers recently demonstrated that an experimental vaccine containing proteins from Ebola and Sudan viruses provides monkeys with some protection against those viruses. But precisely how the vaccine works is unclear, and it has never been tested in humans. Moreover, until now no laboratory has isolated a neutralizing antibody against Sudan virus.

To find such an antibody, Dye and his colleagues at Fort Detrick, Maryland, injected lab mice with a harmless virus engineered to make copies of the Sudan virus coat protein. The coat protein provoked the mice's immune B cells to make various antibodies against it, and the scientists were able to reproduce the mice's repertoire of antibodies by harvesting their B-cells and culturing them in the lab. Testing each type of antibody for its ability to block the infection of cells with Sudan virus, the researchers found one good candidate, antibody 16F6, which not only neutralized Sudan virus in the lab dish but also significantly delayed the deaths of infected mice. They then sent 16F6 to Ollmann Saphire's lab at Scripps Research in California.

"We were very excited about developing this antibody as a potential treatment for Ebola virus," said Dye. "Collaborating with the Ollmann Saphire lab to determine the binding site was the perfect complement to our previous work."

Ollmann Saphire's lab specializes in the use of X-ray crystallography and related techniques to visualize the atomic-scale details of viruses bound by antibodies. These details reveal where on a virus an antibody binds, and if the antibody is one that neutralizes a virus's ability to infect cells, its binding site usually offers important clues to the virus's workings and vulnerabilities.

In the new study, Ollmann Saphire's team found that 16F6 attaches to the Sudan virus in a way that links two segments of the viral coat protein. The virus is known to use one of these segments, GP1, to grab hold of a host cell. When this happens, the cell automatically brings the virus inside, encapsulated within a bubble-like chamber known as an endosome. Normally the cell would destroy the contents of such an endosome, but Sudan virus-like some other viruses-employs its other viral coat-protein segment, GP2, to fuse to the wall of the endosome so that it and the rest of the virus escape into the doomed cell's interior. Antibody 16F6 seems to prevent this fusion process from happening by keeping GP2 bound to GP1.

"The virus is like a wolf in sheep's clothing because its outer part is covered with human sugar molecules, that the antibodies do not see as foreign," said Ollmann Saphire. "The binding site of the 16F6 antibody is one of the few places where viral protein is exposed, and it's exposed because it's a place where GP1 and GP2 need to be free to move." To fuse to the endosomal wall, GP2 must separate from GP1 and uncoil itself. When it is held fast to GP1 by the antibody 16F6, GP2 can't uncoil and perform its function-and so the Sudan virus, instead of escaping into the relatively unprotected interior of the cell, stays within the endosome and is eventually destroyed.

A Strategy Against Ebolaviruses

Ollmann Saphire and her colleagues suspect that 16F6's protein-linking strategy is the best one that antibodies have against ebolaviruses. The antibody's binding site on the Sudan virus coat protein is virtually the same as the binding site of an Ebola-Zaire-neutralizing antibody known as KZ52, which Ollmann Saphire and Scripps Research colleague Professor Dennis Burton found and analyzed three years ago. KZ52 is derived from antibodies made by an African patient who survived an Ebola-Zaire outbreak in 1995, and aside from 16F6 it is the only ebolavirus-neutralizing antibody whose binding site has been determined with X-ray crystallography.

"We think it's not just a coincidence that these two different antibodies, evoked in two different host species by two different ebolaviruses, use the same strategy of linking GP1 and GP2," Ollmann Saphire said.

She and her colleagues now are trying to obtain structural data on several other ebolavirus-neutralizing antibodies, and she suspects that at least one of these also works by linking GP1 to GP2. "There may be other neutralizing sites on ebolaviruses, but so far the only one we've found is this one," she said.

The recognition that ebolavirus-neutralizing antibodies share this protein-linking strategy should guide the further development of vaccines and immunotherapies. "It helps us to understand more precisely what an ebolavirus vaccine or immunotherapy ought to do," Ollmann Saphire said.

The lead authors of the paper, "A shared structural solution for neutralizing ebolaviruses," are Jo?o M. Dias, a research associate in the Ollmann Saphire lab who is now a senior scientist at Heptares Therapeutics in the UK; and Ana I. Kuehne, a researcher in the Dye laboratory at Ft. Detrick. The other authors are Majidat A. Muhammad and Eugene Kang of the Dye lab at Ft. Detrick; Dafna M. Abelson, Shridhar Bale and Marnie L. Fusco of Scripps Research; Anthony C. Wong and Kartik Chandran of the Albert Einstein College of Medicine; Peter Halfmann of the University of Wisconsin at Madison; and Yoshihiro Kawaoka of the University of Tokyo. Funding for the research was provided in part by the U.S. National Institutes of Health and the Defense Threat Reduction Agency.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/RCiz12jaD1M/111120134703.htm

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Sunday, November 20, 2011

Protein Might Ward Off Afternoon Snooze

60-Second Mind60-Second Mind | Mind & Brain

Glucose can block brain cell secretion of orexin, which keeps us alert. But amino acids can stop that block. Christie Nicholson reports.

More 60-Second Mind

The other afternoon I hit a classic mid-afternoon slump. Sleepy and sluggish, I grabbed for a bit of chocolate. But I probably should have had egg whites or maybe a piece of steak. Because a recent study in mice has found that it?s protein, not sugar, that provides the perk.

Brain cells called orexin cells secrete a stimulant that makes us energetic and tells the body to burn calories. If the cells? activity decreases, narcolepsy or sudden sleepiness, is the result. The work is published in the journal Neuron. [Mahesh M. Karnani et al, Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids]

Scientists marked orexin cells in mice brains so they would fluoresce. Then they tracked the cells? activity after feeding the mice different kinds of food.

Turns out that glucose blocks the function of the orexin cells. This effect might be the main reason for the desired post-lunch siesta. But the researchers also found that amino acids stop the glucose action, keeping the cells active and the mice alert. So next time I get that 3 p.m. slow down, I?ll have an egg. If I?m alert enough to remember.

?Christie Nicholson

[The above text is a transcript of this podcast]
?


Source: http://rss.sciam.com/click.phdo?i=89c372fff32a6ce57e8504a4d1447536

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Avaak Announces New Mounting Options for VueZone Camera System

The VueZone system from Avaak is an easy to setup wireless security camera system that we’ve reviewed here on The Gadgeteer. Before today, the VueZone cameras weren’t meant to be used outdoors because of a lack of weather resistance. Now the cameras can go outside when they are housed in the new water-resistant outdoor camera [...]

Source: http://the-gadgeteer.com/2011/11/18/avaak-announces-new-mounting-options-for-vuezone-camera-system/

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Saturday, November 19, 2011

Budke, Serna coached together for decade (AP)

STILLWATER, Okla. ? Kurt Budke believed in Oklahoma State when no one else did, and he wasn't afraid to show it.

Less than two years after his Cowgirls failed to win any of their 16 conference games, Budke led them up against powerhouse Oklahoma and reigning national player of the year Courtney Paris. He supported his upstart team with a fashion statement: the brightest orange blazer he could find.

Behind a scintillating 45-point game from Andrea Riley, the Cowgirls upset the sixth-ranked Sooners for the first time in nine years.

Wherever Budke went, he won.

The charismatic coach who turned the Cowgirls into an NCAA tournament regular was killed along with assistant coach Miranda Serna and two other people in a plane crash in Arkansas late Thursday. The two coaches, who had worked together for more than a decade, had been on a recruiting trip.

Budke frequently offered his players encouragement from the sidelines, but he also could be firm, raising his deep voice. And on more than one occasion, he grabbed a microphone to speak to the Gallagher-Iba Arena crowd after a win.

"Coach Budke was a ball coach. What he did to turn this program around was unbelievable but that's not important right now," said Jim Littell, Budke's assistant who will replace him on an interim basis.

"What's important is he was a father figure for these kids. He had a tremendous knack of taking kids that maybe were struggling in some part of their life and making it better for them. That was his strongest trait."

Serna, 36, was one of his top helpers along the way. She played on one of his four teams that won the junior-college national title at Trinity Valley (Texas) and was his assistant at Louisiana Tech for three straight trips to the NCAA tournament.

The Guadalupita, N.M., native was his recruiting coordinator at Oklahoma State, which has been to the postseason the past five years.

When he took over the program, the Cowgirls had finished with a losing record in five of their previous seven seasons and never finished more than a game over .500 during that span.

The Cowgirls went 0-16 in Big 12 play in his first season, then secured their first bid to the NCAA tournament in 11 years. The next year brought a trip to the round of 16.

"You learn how to lose, and that's a bad habit," he once said of those early struggles. "Sometimes, it's easier to lose than to fight back, so we had to change habits and expectations."

Budke had little to sell but a dream, but it was enough to convince the WNBA-bound Riley to come make her mark. She left as the program's career scoring leader.

"I came to this league because I wanted to coach against the best, night in and night out," he once said. "These players that want to come play for us want to play against the best. That's how we go out and recruit."

A Salina, Kan., native, Budke was a married father of three, including a daughter currently at Oklahoma State.

"I looked at him almost as a mentor," Oklahoma State men's basketball coach Travis Ford said. "I can't tell you how many times I would pick up the phone and ask him how he ran his zone offense. He'd come down to the office or I'd go up to his and we would sit and talk.

"Just somebody who I had the utmost respect for as a person and a husband and father and obviously as a coach. In this profession, the way it gets crazy at times, he had everything in perspective."

Budke played basketball for Barton County (Kan.) Junior College and graduated from Washburn in 1984 with a bachelor's degree in physical education. After some early small-college jobs, he built the JUCO powerhouse at Trinity Valley before hooking up with Louisiana Tech, once one of the top programs in the women's game.

"It just hits home with all of us in this profession that truly we just coach a game," said Kim Mulkey, a former Louisiana Tech player and now the head coach for top-ranked Baylor.

"There's a bigger picture out there and it's not a basketball game, it puts life in perspective. I feel for the Oklahoma State community, how many more tragedies can they endure?"

The crash is the second major tragedy for the sports program in about a decade. In January 2001, 10 men affiliated with the university's men's basketball team died in a Colorado plane crash.

Sherri Coale, the coach at rival Oklahoma, was devastated.

"Kurt was a fantastic basketball coach and he was a tremendous competitor. More importantly, though, he was a devoted father and husband, and a humble but courageous leader of young people," she said.

Texas A&M coach Gary Blair called Serna a rising star and said he talked regularly with Budke. He said the two were going to miss each other, with the Aggies moving to the Southeastern Conference after this season.

"He was a devout family man and the conversation never stopped without us talking about our own kids, not just the players we coached," he said. "Life is precious. We must enjoy it and we must respect it because it can be taken away at any time. I hope the basketball world and the sports world will honor coach Budke and Miranda in the right way and help the rest of us realize how special our families and the extended families of our teams are."

___

Basketball Writer Doug Feinberg in New York contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20111118/ap_on_sp_co_ne/bkw_obit_oklahoma_st_coaches

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Friday, November 18, 2011

Official: Drug cartel tried to skew Mexico vote (AP)

MEXICO CITY ? A Mexican official says drug traffickers tried to influence elections in the western state of Michoacan, a charge some of the candidates and party leaders in the race have already made.

Juan Marcos Gutierrez says a drug cartel conducted "boldfaced interference" in last Sunday's state elections. The Knights Templar cartel dominates most of Michoacan.

Gutierrez calls the threats and pressure used by the traffickers "extremely worrisome."

Gutierrez served about a week as interim interior secretary before handing over the post to newly designated secretary Alejandro Poire on Thursday.

The interior department oversees domestic security in Mexico.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/ap/20111119/ap_on_re_la_am_ca/lt_drug_war_mexico

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Energy storage breakthroughs on the horizon

Charlie Riedel / AP

In this file photo, a group of 260-foot-high wind towers are silhouetted against a bright orange sky at the Elk River Wind farm near Beaumont, Kan. Massive integration of wind power to the electric grid will take breakthroughs in energy storage technologies.

By John Roach

Breakthroughs in energy storage technologies are on the horizon that could turn vast swathes of the world's sun-soaked deserts and windy plains into sources of clean, renewable energy, according to experts focused on our energy future.

No one technology ? ranging from storing a portion of sun's energy collected during the day in molten salt to run solar thermal generators at night to banks of lithium-ion batteries scattered around neighborhoods ? will be the solution.


Rather, "there is going to be a portfolio of energy storage" options, Bruce Dunn, a professor of materials science and engineering at the University of California at Los Angeles, told me Thursday.?

Dunn is the lead author of a review paper in this week's issue of the journal Science that explores the prospects for three battery technologies to become cheap, reliable and efficient enough for wide-scale deployment on the electric power grid.

Battery breakthroughs
Lithium-ion battery technology, for example, is enjoying a boost in research and development for the electrical vehicle market that is driving down manufacturing costs. Utilities will piggyback on those improvements and may even be able to use EVs to store excess wind and solar energy, he noted.

Other technologies such as redox-flow batteries are relatively new and unproven. "On paper it looks to be very inexpensive," he said, but there's very little experience using them at the scale utilities need.

The batteries are based on the use of liquid electrolytes stored in tanks and pumped through a reactor to produce energy.?

As it stands now, there's plenty known about how the batteries work?on the small scale, but not much about how they work?on large scale. Will they maintain the right power levels? Will there be corrosion problems?

Answers to such questions should start to come within three or four years with preliminary results from demonstration projects supported by the Advanced Research Projects Agency-Energy and the Department of Energy.

"It's an experiential thing, there's no way around it. You've got to build big stuff," Dunn said. "And those things are built and they are being tested. That's the good news."

Sodium-sulfur batteries, the third technology in the Science review, are already in limited use by utilities around the world, including Japan where they are sold commercially, but the technology is costly, Dunn said. Manufacturing prices have to fall before they can be embraced.

In time, he said, prices will fall, just as they have for technologies such as personal computers. And as prices for big, utility-scale batteries fall, they'll be incorporated onto the electric grid, allowing the integration of renewable sources of power such as wind and solar.

The use of batteries on the grid will also reduce the need to construct generation capacity that sits idle most of the time but puts off carbon excess emissions of greenhouse gases as they are cycled up and down to meet peak demands, the researchers note.

Hydrogen storage
Another way to store energy is in the form of hydrogen, which has long been eyed for the fuel cells that some believe will power most cars in the future. A hurdle is how to cheaply and efficiently get hydrogen, which is abundant but almost always bound to something else.

One solution may come from researchers at the Massachusetts Institute of Technology who are working on so-called artificial leaf technology that splits water into bubbles of oxygen and hydrogen. The hydrogen can be stored and used to power fuel cells.

Questions remain about how efficient the system is and how inexpensively they can generate hydrogen, notes Robert Service in a news story about the technology in Science.?

One study, he noted, found that hydrogen can be produced from natural gas about half as cheaply using a mature technology called steam reforming than the best-case scenarios envisioned for the artificial leaf technologies.

"That's not saying artificial photosynthesis isn't worth pursuing ? only that fossil fuels are the leading energy source for a reason and they won't be easy to dethrone," he writes.

More bang for the fossil fuel buck
Eric Wachsman, a sustainable energy researcher at the University of Maryland, argues that technological improvements are making fuel cells that run on all types of fuels, including conventional fuels such as gasoline, in addition to hydrogen, a viable option everywhere from power grids to transportation.

In separate Science review article, he explains that the breakthrough comes from new electrolyte materials that allow solid oxide fuel cells to be operated at lower temperatures.

Solid oxide fuel cells such as Bloom Energy's device that was rolled out last year, he told me, have a power density of about 0.2 watts per square centimeter while operating at about 950 degrees Celsius. His team has developed a solid oxide fuel cell that gets 2 watts per square center at 650 degrees Celsius.

"It is an order of magnitude higher power density at a much lower temperature," he said, adding that his team has also developed electrolytes that make operation at 350 degrees Celsius viable.

And if solid oxide fuel cells can operate at lower temperatures, they become attractive for use in transportation where using a fuel cell to power a car is two and a half to three times more efficient than using fuel to run an internal combustion engine, he noted.

Wachsman is hoping the government will continue to support research in the solid oxide fuel cell technology to help bring down the costs and scale up the technology,?though noted the prospects are grim.

"There is no funding for solid oxide fuel cells in the current DOE budget," he said.

The dearth of government funding for energy innovation is taken up by Bill Gates, Microsoft chairman and co-chair of the Bill and Melinda Gates Foundation, in a Science editorial that plugs his call to increase R&D spending from $5 billion to $16 billion a year.

"History has repeatedly proven that federal investments in research return huge payoffs with incredible associated benefits for U.S. industries and the economy," he writes. "Yet over the past three decades, U.S. government investment in energy innovation has dropped by more than 75 percent."

Without further government investment, will the needed breakthroughs in energy storage remain on the horizon?

More stories about energy technology:


John Roach is a contributing writer for msnbc.com. To learn more about him, check out his website. For more of our Future of Technology series, watch the featured video below.

As the over-65 population expands, new gadgets and systems will allow seniors to live at home and receive improved healthcare. From sleep-sensing beds to robots piloted by grandchildren, we look at how "health surveillance" can improve quality of life.

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Source: http://futureoftech.msnbc.msn.com/_news/2011/11/17/8864312-energy-storage-breakthroughs-on-the-horizon

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